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Background Non-erosive reflux disease (NERD) includes a heterogeneous patient group with varying clinical and pathophysiological characteristics. This study aims to elucidate the pathogenesis of persistent NERD despite of continuous proton-pump inhibitors (PPI) treatment using 24-h combined multichannel intraluminal impedance-pH monitoring (MII-pH). Methods We enrolled fifty-four consecutive...
Self-expandable metallic stents (SEMS) are the currently recommended treatment modality for palliation of dysphagia resulting from unresectable malignant esophageal obstruction. The most common post-SEMS-placement complications are migration, perforation, bleeding, and tumor ingrowth or overgrowth. We report herein a patient with advanced lung cancer invading the esophagus with the very rare late...
Esophageal self-expandable metal stent placement is an effective treatment for palliation of malignant dysphagia, which has a low insertion-related complication rate. However, stent-related perforation can be a life-threatening event. We experienced a patient with advanced esophageal cancer who developed an iatrogenic esophageal perforation resulting from incorrect stent insertion. After removal of...
Background For prevention of surgical site infections, the current guidelines of Center of Disease Control recommend the maintenance of therapeutic levels of prophylactic antimicrobial agents throughout operations and, at most, for a few hours after incision closure. However, in literature supporting these recommendations, most reports have described combinations of various types of surgical procedures...
Thyroid metastasis of esophageal cancer is rare. We report herein a case of synchronous thyroid metastasis of esophageal squamous cell carcinoma. A 54-year-old man with lower thoracic esophageal cancer and left thyroid tumor was admitted to our hospital. We diagnosed synchronous double cancer comprising esophagus squamous cell carcinoma and thyroidal papillary cancer. Simultaneous excision of both...
Background We compared the clinicopathological features and outcomes of patients with submucosal tumor (SMT) of the thoracic esophagus treated by thoracoscopic enucleation. Methods Of 11 patients with endoscopically detected SMTs in the thoracic esophagus, 6 underwent thoracoscopic enucleation and were endoscopically followed up. Results The thoracoscopically enucleated tumors...
Refractory esophageal ulcerations occur rarely after cardiovascular surgery, occasionally leading to perforation. There is little consensus on their optimal management. Herein, we present a case of refractory esophageal ulceration after cardiovascular surgery. A 62-year-old woman with Marfan’s syndrome was referred to our hospital with cardiac failure due to aortic regurgitation. She underwent root...
Backgrounds The objectives of this study were to delineate differences in the morphologic characteristics of reflux esophagitis between a rat gastroesophageal reflux (GER) model and a duodenoesophageal reflux (DER) model and to evaluate the effects of H2-receptor antagonists on morphologic characteristics of reflux esophagitis in DER model. Methods Wistar rats were divided into 3 groups:...
Background An ulcer occasionally develops in the gastric tube as an esophageal substitute after esophagectomy. The aim of the present study was to investigate the risk factors for a gastric tube ulcer. Methods We reviewed the medical records of all 826 patients who underwent esophageal reconstruction using a gastric tube following esophagectomy, in Kurume University Hospital between 1985...
Background Esophageal reconstruction using intestine is often performed for esophageal cancer patients in cases where the stomach cannot be used. We have previously performed reconstruction using ileocolon with supercharge and drainage as our first choice in those cases. However, a less invasive, simpler, and safer reconstructive technique using jejunum without vascular anastomosis has recently...
The patient was a 65-year-old man, who had undergone right nephrectomy for renal cancer in 2002. At that time, histopathological examination revealed clear cell carcinoma (pT3a, pN0, M0, and pStage III). Postoperatively, he received natural interferon alpha (6 million units 3 times a week) from November 2002 to February 2005, and showed no evidence of recurrence. However, he noticed dysphagia in March...
We describe a rare case of thyroidal Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV + DLBCLe) in which diagnosis was difficult and spontaneous esophageal fistula developed. A 79-year-old woman presented with acute swelling of the anterior neck with tenderness, general fatigue, and continual fever. Malignant lymphoma of the thyroid was suspected. Histologically,...
Background Esophageal malignant melanoma is an extremely rare disease and no scientific society has systematically collected data on it previously. Method The 141 institutes belonging to the Japan Esophageal Society conducted a questionnaire on the details of esophageal malignant melanoma during the 10-year period from 1998 to 2007. Results The questionnaire return rate was 92...
Submucosal abscess of the esophagus is extremely rare, and treatment has yet to be well established. A 58-year-old man with no relevant past medical history visited an otolaryngological clinic with a chief complaint of throat irritation. Computed tomography revealed submucosal abscess extending the full length of the esophagus after abnormally high white blood cell count and C-reactive protein levels...
Background There is a large variability in clinical practice and in the literature, and no controlled trial with adequate sample size for performing pneumatic balloon dilation (BD) for achalasia. We aimed to evaluate the efficacy and safety of pneumatic BD for achalasia over a 12-year period. Methods We undertook a retrospective review of the medical records of 45 patients who underwent...
Background Preoperative chemotherapy using 5-fluorouracil and cisplatin is a standard treatment for stage II/III esophageal squamous cell carcinoma (ESCC) in Japan. However, stronger therapies are needed for advanced ESCC. This retrospective study aimed to evaluate the feasibility and safety of neoadjuvant chemoradiotherapy with R-DDP. Methods Patients diagnosed with clinical stage...
Achalasia is a deglutition disorder of unknown aetiology but many aspects of its epidemiology would suggest that it has a specific cause which is operational later in life. This review considers the limited number of epidemiological studies that have been performed and examines ethnic differences as well as the potential role of migration. The possible role of viral infection in its aetiology is considered...
Gastro-tracheobronchial fistula following esophagogastrostomy is usually fatal, making conservative treatment inadvisable. A 68-year-old man underwent esophagectomy with gastric conduit reconstruction in the posterior mediastinum and neck anastomosis. Despite anastomotic leakage on postoperative day 8, the patient was stable and was managed conservatively. On day 28, a gastric tube–bronchial fistula...
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